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In addition buy 40mg propranolol mastercard heart attack 720p kickass, the outcomes from this project could be used to generate new economic knowledge that will promote the optimal design of cancer control strategies to improve the quality of a woman’s life if her breast cancer progresses to a metastatic stage discount propranolol 80mg otc blood pressure chart diabetes. Funding Preferences None Research Plan Length and Supporting Material The Research Strategy Section of the Research Plan is limited to a maximum of 12 pages purchase propranolol 80 mg with visa heart attack at 20. The appendices should include materials that show evidence of the applicant’s ability to successfully conduct the proposed project and other evidence deemed necessary to support the contents of the proposal order propranolol discount blood pressure medication edarbyclor. Availability of Funds It is anticipated that approximately $500,000 is available to fund 1 (one) Prevention Research Center for a 2-year project period. The award for the recipient is expected to be approximately $350,000 for year one and $150,000 in year two. Research Status It is expected that this project will be exempt research; the project will involve analysis of previously collected treatment and cost data without identifiers. Treatment costs of breast cancer among younger women aged 19 to 44 years enrolled in Medicaid. Productivity costs associated with breast cancer among survivors aged 18–44 years. Breast cancer diagnosis in women < or = 40 versus 50 to 60 years: increasing size and stage disparity compared with older women over time. Living with metastatic breast cancer: A qualitative analysis of physical, psychological, and social sequelae. Incidence of breast cancer with distant involvement among women in the United States, 1976 to 2009. Medical costs and productivity losses of cancer survivors - United States, 2008–2011. Silent voices: Women with advanced (metastatic) breast cancer share their needs and preferences. Older Women With Breast Cancer: Slow Progress, Great Opportunity, Now Is the Time. These concerns, coupled with provider and parent attitudes and behaviors related to confidential care, could limit adolescent access to currently available services. Project Objectives/Outcomes The purpose of this project is to better understand provision of confidential sexual health services by pediatricians and family medicine providers to female and male adolescents 11-17 years of age. Specifically, the project will describe perspectives from three key populations—adolescents, providers, and parents. For each study population--parents, providers, and adolescents--indicate the specific research questions to be addressed and method(s) of data collection (quantitative and/or qualitative). It is likely that both quantitative and qualitative data collection components with providers will be used. Please justify the selection of data collection methods based on the proposed research questions. Provide details on each data collection component, including sampling and recruitment plans, target sample size with justification, survey modes (e. Target populations Describe and provide evidence of access to clinic-based populations, including each of the following: • Pediatric and family medicine providers • Female and male adolescents 11-17 years of age • Parents of female and male adolescents 11-17 years of age It is anticipated that sample sizes will vary depending on the proposed data collection methods. For example, a quantitative data collection component would likely occur with a relatively large sample (e. Similarly, it is expected that a qualitative component could be conducted with a sufficient sample (e. Collaboration/Partnerships 50 of 57 Collaboration/Partnerships Describe and provide evidence of collaboration/partnerships with organizations that will facilitate recruitment of providers, adolescents, and parents, including national professional organizations or other organizations/networks able to reach a diverse sample of pediatric and family practice providers and clinics that will yield diverse samples for each of the three target populations. Recruitment Plan Describe plans to recruit research participants as part of the study design and methods section. Recruitment plans for each data collection component should be addressed and ensure guardian consent is discussed when conducting research with minors (e. For each person, describe their demonstrated knowledge and experience relevant to the proposed study. Applicant is also to provide description and timeline for key activities for entire project period. Evaluation Plan/Performance measurement Provide an evaluation plan to assess project performance and progress. Dissemination and Translation plans Describe a plan for disseminating the results of this project to relevant stakeholders, including researchers, providers, parents and adolescents. Increasing receipt of preventive services, including behavioral counseling, can reduce risk behavior and improve sexual and reproductive health outcomes. The appendices should include materials that show evidence of the applicant’s ability to successfully conduct the proposed project and other evidence deemed necessary to support the contents of the proposal. Availability of Funds It is anticipated that approximately $800,000 is available to fund 1 Prevention Research Center for a 2-year project period. Applicants should provide a federal-wide assurance number for each performance site included in the project. Behavioral sexual risk-reduction counseling in primary care to prevent sexually transmitted infections: a systematic review for the U. Human papillomavirus vaccination and cervical cytology outcomes among urban low-income minority females. Does delivering preventive services in primary care reduce adolescent risky behavior? Sexually transmitted infection testing among adolescents and young adults in the United States. Confidentiality and adolescents’ willingness to consent to sexually transmitted infection testing. Influence of physician confidentiality assurances on adolescents’ willingness to disclose information and seek future health care. Bright Futures: Guidelines for Health Supervision of Infants, Children, and Adolescents. Messages might be appropriate for delivery through communication campaigns (electronic or print) or embedded in other intervention approaches such as school or community-based curriculum, clinic-based programs, and/or health care provider or counselor communication. Project Objectives/Outcomes The specific objectives of this project are to: • Identify known barriers and facilitators for the target protective behaviors that are currently found in peer-reviewed literature. The study design should describe an approach to synthesizing the current state of the literature on known barriers and facilitators for the identified protective behaviors that can serve as a foundation for both message development and the qualitative research. The application is expected to include a description of suggested search terms, databases, coding and synthesis processes, and specific research questions to be addressed. The study design should also reflect how it will build on the factors identified in the literature to provide an in-depth description of youth perspectives on (1) the most influential barriers and facilitators for the target protective behaviors (allowing youth to reflect on barriers and facilitators that emerged in the literature as well as additional barriers and facilitators that may be important), (2) what type of content they want and/or need in messages related to the most influential barriers and facilitators, (3) who (e. The design is expected to include individual interviews or focus groups with youth.
Struchiner buy generic propranolol 40mg online blood pressure medication valsartan, Epidemiological eﬀects of vaccines with complex direct eﬀects in an age-structured population buy generic propranolol 80 mg on-line hypertension essential benign, Math order genuine propranolol online blood pressure ranges for young adults. Hethcote order 40mg propranolol otc arteria humeri, A thousand and one epidemic models, in Frontiers in Theoretical Biology, S. Hethcote, Modeling heterogeneous mixing in infectious disease dynamics, in Models for Infectious Human Diseases, V. Hethcote, Simulations of pertussis epidemiology in the United States: Eﬀects of adult booster vaccinations, Math. Van Ark, Epidemiological models with heterogeneous popula- tions: Proportionate mixing, parameter estimation and immunization programs, Math. Li, An intuitive formulation for the reproductive number for the spread of diseases in heterogeneous populations, Math. Koopman, The reproduction number in deterministic models of contagious diseases, Curr. Hethcote, Inﬂuence of Heterogeneous Mixing on Measles Transmission in an African Context, preprint, 2000. Lauwerier, Mathematical Models of Epidemics, Mathematisch Centrum, Amsterdam, 1981. Levin, Dynamical behavior of epidemiological models with nonlinear incidence rates, J. Yorke, Recurrent outbreaks of measles, chickenpox and mumps I: Seasonal variation in contact rates, Am. Hethcote, Dynamic models of infectious diseases as regulators of population sizes, J. Thieme, Asymptotically autonomous semiﬂows: Chain recurrence and Lyapunov functions, Trans. Mollison, Dependence of epidemic and population velocities on basic parameters, Math. Schaffer, Chaos versus noisy periodicity: Alternative hypotheses for childhood epidemics, Science, 249 (1990), pp. Becker, Assessment of two-dose vaccination schedules: Availability for vaccination and catch-up, Math. Hethcote, Modeling the eﬀects of varicella vaccination programs on the incidence of chickenpox and shingles, Bull. Schuette, Modeling the Transmission of the Varicella-Zoster Virus, preprint, 2000. Thieme, Asymptotic estimates of the solutions of nonlinear integral equations and asymptotic speeds for the spread of populations, J. Thieme, Global asymptotic stability in epidemic models, in Equadiﬀ 82 Proceedings, H. Thieme, Local stability in epidemic models for heterogeneous populations, in Mathe- matics in Biology and Medicine, V. Thieme, Stability change of the endemic equilibrium in age-structured models for the spread of S-I-R type infectious diseases, in Diﬀerential Equations Models in Biology, Epidemiology, and Ecology, S. Thieme, Epidemic and demographic interaction in the spread of potentially fatal diseases in growing populations, Math. Vanderplank, Plant Diseases: Epidemics and Control, Academic Press, New York, 1963. Waltman, Deterministic Threshold Models in the Theory of Epidemics, Lecture Notes in Biomath. Webb, Theory of Nonlinear Age-dependent Population Dynamics, Marcel Dekker, New York, 1985. Wickwire, Mathematical models for the control of pests and infectious diseases: A survey, Theoret. Hethcote, Population size dependent incidence in models for diseases without immunity, J. Y ouruse ofth is materialconstitutes acceptance ofth atlicense and th e conditions ofuse ofmaterials onth is site. U serassumes allresponsibility foruse,and allliability related th ereto,and mustindependently review allmaterials foraccuracy and efficacy. U seris responsible for obtainingpermissions foruse from th ird parties as needed. IntroductiontoInfectiousD iseaseE pidemiology K enrad N elson,M D Joh ns H opkins U niversity SectionA H istory ofInfectious Diseases inth e 20th C entury CrudeD eathRate*forInfectiousD iseases:U. Trends ininfectious disease mortality inth e U nited States duringth e 20th century. Trends ininfectious disease mortality inth e U nited States duringth e 20th century. Trends ininfectious disease mortality inth e U nited States duringth e 20th century. Trends ininfectious disease mortality inth e U nited States duringth e 20th century. Trends ininfectious disease mortality inth e U nited States duringth e 20th century. D eaths:1900and1997 Th e 10 leading causes ofdeath as a percentage ofalldeath s inth e U nited S tates,1900 and 1997 1 1 ne u m onia e a r t is e a s e 2 e r c los is a nc e r 3 ia r r he a nt e r iis r oke 4 e a r t is e a s e hr oni ng is e a s e 5 r oke nint e nt iona l nj r y 6 i e r is e a s e ne u m onia & nf l e nza 7 nj r ie s ia b e t e s 8 a nc e r V nf e c ion 9 e nili i id e 1 ipt he r ia hr oni i e r is e a s e S ou r c e : 9 U. D eathRatesforCommonInfectiousD iseases Death R ates forC om m onInfectious Diseases inth e U nited S tates in1900,1935,and 1970 M ortality rate per100,000 population 1900 1935 1970 Influenz a and pneum onia 202. A ph ysicianfrom south ernC h ina wh o ch ecked into a h otelinH ong K ong was illwith pneum onia and infected 13 oth erpeople,probably th rough airborne transm ission. M onkey pox Prairiedogs 25 E mergenceof New InfectiousD iseases Overthelast150y ears,therehavebeenmany globalchangesthathaveenhancedtheprobability of theemergenceof new infectiousdiseasesof humansandanimals. ColiO 157:H7 34 SectionC InternationalInfectious Diseases G lobalThemperatureAnomalies C lim a t e c ha ng e c a n ha v e a m a jor im pa c on t he d is t r i ion of infe c iou s d is e a s e v e c or s like m os qu ioe s. I a s t he r e for e d e c id e d ha t his w a s a fu ile e ffor t e c a u s e e llow fe v e r w ou ld pe r s is t d e s pie e lim ina t ion of e d e s a e g pt iin r b a n a r e a s. F everofundeterm ined origin 47 AnE pidemiologist’sView M eansof Spreadof InfectiousD iseases Contact • D irect • Indirect • F omites • Body secretions(blood, urine,saliva,etc. Trypanosom iasis 53 SummerInfectionChainsforW esternE quineE ncephalitis F r om e s s , old e n, r e s t on O Y O O O O E nna ls of he e w Y or k a d e m of ie nc e s 54 Reservoirsof InfectiousD iseases 1. Infectivity − Th e propensity fortransm ission − M easured by th e secondary attack rate ina h ouseh old, sch ool,etc. P ath ogenicity − Th e propensity foranagentto cause disease orclinical sym ptom s − M easured by th e apparent:inapparentinfection ratio 3. V irulence − Th e propensity foranagentto cause severe disease − M easured by th e case fatality ratio 60 D efinitionsof SomeRelevantTherms Incubationperiod − Th e period betweenexposure to th e agentand onsetof infection(with sym ptom s orsigns ofinfection) S econdary attack rates − Th e rates ofinfectionam ong exposed susceptibles after exposure to anindex case,such as ina h ouseh old or sch ool 61 D efinitionsof SomeRelevantTherms(cont. Incontrastto a persistentinfection,only th e geneticm essage is presentinth e h ost,notviable organism s. Th e resistance ofa groupto invasionand spread ofaninfectious agent,based uponth e resistance to infectionofa h igh proportionof individualm em bers ofth e group.
Its main side Removing only the tumor leaves the rest of the pituitary gland intact so that efect is fatigue order propranolol 40 mg with visa prehypertension follow up. This is successful for 70–90% of people when performed by the best pituitary surgeons buy propranolol 40 mg visa hypertension webmd. The success rates refect the Another recently introduced medication order genuine propranolol on-line blood pressure chart age 60, mifepristone cheap 40mg propranolol fast delivery arrhythmia during stress test, does not afect the experience of the surgeon performing the operation. However, the tumor tumor itself but blocks the efects of cortisol in the entire body, and improves can return in up to 15% of patients, probably because of incomplete tumor the complications associated with excess cortisol. Because there is no anti-tumor efect, the tumor itself has to be carefully followed, and there Other options for treatment include radiation therapy to the entire pituitary are other important side efects of the treatment as well. These drugs are best gland or targeted radiation therapy (called radiosurgery), when the tumor is administered by a pituitary or neuro-endocrinologist skilled in their use. Most people will start to feel gradually better after surgery and the hospital stay may be quite short if there are no complications. It can take some time It is important to note that, if you are taking replacement cortisol, there to feel completely back to normal, to lose weight, to regain strength, and to may be a number of occasions when you need additional replacement. It is important to remember that can include stressful situations, such as surgical procedures – whether or not the high cortisol levels physically change the body and brain, and that these related to Cushing’s syndrome – dental procedures, and so on. This is a normal feature of the recovery discuss your specifc condition with your endocrinologist and ensure you period and patience is defnitely a virtue here. I have been told I might have Cushing’s syndrome and have been referred to an body adjusts to the lower cortisol levels. The most common way to remove pituitary tumors is through the Until the pituitary and adrenal glands recover, the body does not respond transsphenoidal approach. This involves entering the pituitary gland by going normally to stress – such as illness – by increasing cortisol production. As through the nose or underneath the upper lip, and approaching the pituitary a result people who sufer with ‘fu’, fever or nausea may have to double gland through the sphenoid sinus. Using a microscope or endoscope, the surgeon the oral dose of the glucocorticoid when they are sick. However, this will explore the pituitary gland, hopefully fnd the tumor, and remove it. On occasion, people can sufer vomiting or severe diarrhea that prevents them from absorbing the glucocorticoids taken by mouth. For this reason, patients should wear a MedicAlert Since these tumors are very small, it can be difcult to fnd them, and the bracelet until glucocorticoid replacement is stopped. Also, if the People who have had their adrenal glands removed will have to take a posterior part of the pituitary is damaged, anti-diuretic hormone can be lost. People whose adrenal glands have been removed may have initial nasal spray or pill. These hormone functions of the pituitary can be replaced symptoms that are similar to those after pituitary surgery, and they should with medication. Since the pituitary gland is bordered by the optic nerves and carotid arteries, There are a number of options if the initial transsphenoidal operation is there is a very small risk that these structures could be damaged (less than unsuccessful. Alternatively, radiation therapy of the The pituitary is separated from the spinal fuid by a thin membrane. This is efective in about half the patients membrane is damaged during the surgery, a spinal fuid leak can result. If spinal within a few years, but medical control of cortisol levels is required while fuid leakage occurs and is undetected, a serious infection, meningitis, can awaiting the benefcial efects of radiation. Most surgeons take a small piece of fat from the abdominal wall to use themselves can be removed. This stops the body from making any cortisol, and as a plug to prevent this leakage from occurring. The risk of this happening is so the symptoms of Cushing’s disease resolve, although the pituitary tumor about 1%. Since the pituitary gland is involved in water and sodium balance, itself remains untreated. Removal of the adrenals may lead to a more rapid this can be afected transiently by the surgery as well, and your endocrinologist growth of the remaining pituitary tumor, which will require careful monitoring will monitor your sodium levels for a few weeks after the surgery. Finally, there are now new medical options to treat the risks are minimized in the hands of an experienced surgeon. Administration of the drug cabergoline, initially used to treat prolactin- producing tumors, is efective in some cases of Cushing’s disease. Pasireotide acts directly on the pituitary tumor to stop its growth and lower Direct efects of the surgery include nasal congestion and possibly headache. Mifepristone acts to block the peripheral efects of cortisol These symptoms will resolve after 1–2 weeks. Choosing between these options however, the cortisol levels will drop dramatically. Patients can experience requires a careful discussion between the patient, endocrinologist, and surgeon. My surgery was unsuccessful and my endocrinologist has suggested treatment the surgery. If the operation is successful, the patient will have to take cortisol with cabergoline. Some patients who have a response in the frst one or two months Your endocrinologist will test your blood, urine, and/or salivary cortisol levels will “relapse”, meaning that the drug may not successfully control cortisol levels a few days after the surgery. The psychological efects can be very troublesome and can persist for months, even if cured. It successfully normalizes urine cortisol for 12 months in about 20% Adrenal glands Glands situated just above each of the kidneys and which produce various essential hormones including cortisol and aldosterone. It is particularly efect is the development of high blood sugar levels requiring treatment (or important in times of stress and illness. My surgery was unsuccessful and my endocrinologist has suggested treatment pituitary-dependent Cushing’s disease. Cushing’s disease Cushing’s syndrome when caused by a tumor of the pituitary gland. Because it is used to lower blood sugar levels, those levels should be Endocrinologist A doctor who specializes in treating hormone illnesses. Its ability to normalize other features of Cushing’s syndrome is not clear, and additional treatment may be needed to Florinef A medication, also known as fudrocortisone, that controls salt and fully treat the signs and symptoms of Cushing’s syndrome. Glucocorticoid A medicine that has efects similar to those of cortisol, for example, hydrocortisone, prednisone and dexamethasone. After successful surgery, cortisol levels are low and a glucocorticoid is given to replace cortisol until the pituitary and adrenal glands resume normal function (in the case of Cushing’s disease) or as life-long replacement (if the adrenal glands are removed). Pituitary gland A small gland that is situated under the brain and which controls hormone production in many other parts of the body. Radiosurgery Precisely targeted radiation aimed directly at the tumor, usually given in a single dose. Radiotherapy Radiation treatment, usually used after surgery, which prevents regrowth of the tumor. Radiotherapy has a long-acting efect and may cause reduction of some of the other pituitary hormones over time, thus requiring them to be replaced.
Focus on understanding review one who will make the effort to read and think problems 3 cheap 40mg propranolol fast delivery pulse pressure emt. Judge suggestions critically reads your target journal but is not part of the “research culture” particular to your topic discount propranolol 40 mg mastercard arrhythmia heart attack. Internal reviewer • Expert reviewers cheapest generic propranolol uk pulse pressure graph, whose primary job is to help • General • Expert prepare you for reviews by journal editors and peer reviewers discount generic propranolol uk arteria pancreatica magna. Tactics to m axim ize the productivity of the internal (What are the biggest threats to validity in this review process. You can maximize the commitment of Im prove the paper your internal reviewers clarifying your expectations and Don’t rush the Allow yourself the tim e to step by extending simple courtesies. Unannounced mail, electronic or conven- Revise frequently Look hard at your structure tional, is both poor form and is likely to go to the bottom again of the pile. Also recognize that good Check for consistency reviewers have many demands on their time. If the reviewer can- Respond to reviews Strike a balance between not accommodate your needs, move on. You may want to focus expert review- ers on specific technical or theoretical questions you Im prove your skills have (Is this an adequate description of the logistic Read and critique Serve as an internal reviewer model? First, pro- Serve as a peer reviewer vide your paper in a format that is easy to review. Triple- spaced text (to provide room for comments) and numbered pages (so you can each locate text) are particularly impor- tant. Explore the motivation behind trating for a reviewer than to spend a lot of time on a sec- each comment and work together to articulate what the tion only to learn later that it has been deleted. The conversation should continue until you understand Receiving Feedback what the reviewer had in mind, not until one of you has convinced the other. Without some limits, you may lose There is an even more important reason to have a con- the opportunity to learn about other issues. Although we appreciate guid- Encourage reviewers to mark up the paper, but go over ance, many of us get bogged down with conflicting these comments in a conversation. Taken at face value, problems identified by tion, not only do you risk missing certain points (scrib- reviewers are generally valid; their proposed solutions, bled-up drafts are often difficult to read), you miss the on the other hand, may be wrong. Take what are clearly There are other important tactics for obtaining good suggestions but think of alternatives for those that feedback. Such feedback only better prepares you for the journal’s Getting Better review process. To give yourself the any time a reviewer is motivated to mark the draft, a opportunity to become a better writer, make the time. To improve the paper, don’t rush the writing • Start writing before your project is com pleted. Too many authors are impatient to get the • Focus your attention on what readers are m ost paper off their desk and onto the editor’s. This opportunity for digestion can be efficiently sched- • Im prove the paper by learning how to get and uled while your internal reviewers are doing their incorporate useful feedback. Sift through the words requirements for manuscripts submitted to biomedical jour- until each can produce a “proper account of itself. Responsibilities of medical jour- clear to the editor (in a cover letter) what you changed, nals to readers. How to encourage a referee: use your word proces- To improve your skills, help others. I would also like to acknowledge the assistance the opportunity to serve as a peer reviewer, particu- given me by the current associate editors of ecp. Suggested citation: United Nations Office on Drugs and Crime, World Drug Report 2016 (United Nations publication, Sales No. It exam- ines the use of the “dark net” and new technologies for drug The session was only the third in the history of the General trafficking, as well as the potential of illicit drug profits to Assembly to focus on drugs, and the resulting outcome fund terrorism and violent extremism. This is a topic of particular relevance: as Governments In the outcome document, Member States reaffirmed their noted in the outcome document, “efforts to achieve the commitment to addressing persistent, new and evolving Sustainable Development Goals and to effectively address challenges in line with the three international drug control the world drug problem are complementary and mutually conventions, which were recognized as allowing States par- reinforcing”. The evidence is clear: illicit drug cultivation and manufacturing can be eradicated only The operational recommendations contained in the out- if policies are aimed at the overall social, economic and come document encompass measures to address demand environmental development of communities; confronting and supply reduction, as well as to improve access to con- drug trafficking and its associated violence requires strong, trolled medicines while preventing their diversion; they transparent and fair criminal justice institutions and tar- cover human rights, youth, children, women and commu- geted efforts to dismantle transnational organized criminal nities and highlight emerging challenges and the need to organizations; prevention and treatment of drug use work promote long-term, comprehensive, sustainable, develop- if they are based on scientific evidence and are gender- ment-oriented and balanced drug control policies and pro- sensitive; and the excessive use of imprisonment for drug- grammes that include alternative development. The text highlights the importance of drug abuse preven- tion and treatment; encourages the development, adoption There is clearly much work to be done to tackle the many and implementation of alternative or additional measures evolving and emerging challenges posed by drugs. The out- with regard to conviction or punishment; and promotes come document and its operational recommendations offer proportionate national sentencing policies, practices and a solid foundation, one built on agreed frameworks, guidelines for drug-related offences. Now the international community must come together to make good on its commitments. This report, as with all of the Office’s expertise and on-the- ground experience in addressing the many aspects of the The World Drug Report 2016, which provides a compre- world drug problem, is at the disposal of Member States hensive overview of major developments in drug markets, as they strive to meet this call to action. This year’s report offers insight into the wide-ranging impact of drugs not only on the health and well-being of individuals, but also on the people around them — families Yury Fedotov and communities. While the challenges posed by new psychoactive substances remain a serious concern, heroin continues to be the drug that kills the most people. Market analysis by drug type 26 Opiates 26 Cocaine 35 Cannabis 43 Synthetic drugs: amphetamine-type stimulants and new psychoactive substances 52 2. Core team Research, study preparation and drafting Coen Bussink David Macdonald Chloé Carpentier Kamran Niaz Liliana M. Dávalos Thomas Pietschmann Philip Davis Martin Raithelhuber Angelica Durán-Martínez Clinton W. The Research and Trend Analysis Branch acknowledges the invaluable contributions and advice provided by the World Drug Report Scientific Advisory Committee, which was formed in 2015 with the following members: Jonathan Caulkins Paul Griffiths Marya Hynes Vicknasingam B. A dotted line represents All uses of the word “drug” in this report refer to sub- approximately the line of control in Jammu and Kashmir stances under the control of the international drug control agreed upon by India and Pakistan. Disputed boundaries (China/India) are repre- All analysis contained in this report is based on the official sented by cross-hatch owing to the difficulty of showing data submitted by Member States to the United Nations sufficient detail. Office on Drugs and Crime through the annual report The designations employed and the presentation of the questionnaire unless indicated otherwise. References to dollars ($) are to United States dollars, unless Countries and areas are referred to by the names that were otherwise stated. R stands for the correlation coefficient, used as All references to Kosovo in the present publication should measure of the strength of a statistical relationship between be understood to be in compliance with Security Council two or more variables, ranging from 0 to 1 in case of a resolution 1244 (1999). Roughly the equivalent of the combined … and encourage the sharing of best practices populations of France, Germany, Italy and the United and lessons learned. Overdose deaths contribute to between roughly a reviews the scientific evidence on polydrug use, treatment third and a half of all drug-related deaths, which are attrib- demand for cannabis and developments since the legaliza- utable in most cases to opioids. The time period shortly tion of cannabis for recreational use in some parts of the after release from prison is associated with a substantially Prevalence of injecting drug use, 2014 or latest available year Percentage of populaton aged 15-64 ≤ 0. The dotted line represents approximately the Line of Control in Jammu and Kashmir agreed upon by India and Pakistan.
For the full text of the requirements cheap propranolol 40mg fast delivery heart attack high the honeymoon is over, please review the following website: https://www generic 40mg propranolol mastercard paediatric blood pressure chart uk. Plain Writing Act The Plain Writing Act of 2010 cheap propranolol online master card blood pressure 50 year old male, Public Law 111-274 was signed into law on October 13 purchase propranolol with a mastercard blood pressure medication you can drink alcohol, 2010. The law requires that federal agencies use "clear Government communication that the public can understand and use" and requires the federal government to write all new publications, forms, and publicly distributed documents in a "clear, concise, well-organized" manner. These policies build on the current federal commitment to reduce exposure to secondhand smoke, which includes The Pro-Children Act, 20 U. Tobacco: 23 of 57 Tobacco: Tobacco-free indoors – no use of any tobacco products (including smokeless tobacco) or electronic cigarettes in any indoor facilities under the control of the applicant. Tobacco-free indoors and in adjacent outdoor areas – no use of any tobacco products or electronic cigarettes in any indoor facilities, within 50 feet of doorways and air intake ducts, and in courtyards under the control of the applicant. Tobacco-free campus – no use of any tobacco products or electronic cigarettes in any indoor facilities and anywhere on grounds or in outdoor space under the control of the applicant. Nutrition: Healthy food service guidelines that at a minimum align with Health and Human Services and General Services Administration Health and Sustainability Guidelines for Federal Concessions and Vending Operations for cafeterias, snack bars, and vending machines in any facility under the control of the recipient organization and in accordance with contractual obligations for these services. The following are resources for healthy eating and tobacco free workplaces: - http://www. However, no applicants will be evaluated or scored on whether they choose to participate in implementing these optional policies. This includes ensuring your programs are accessible to persons with limited English proficiency. Recipients of federal financial assistance must take the reasonable steps to provide meaningful access to their programs by persons with limited English proficiency. For purposes of this announcement, “public health data” means digitally recorded factual material commonly accepted in the scientific community as a basis for public health findings, conclusions, and implementation. Cooperative Agreement Therms and Conditions The following special terms of award are in addition to, and not in lieu of, otherwise applicable U. Recipient Organization will obtain appropriate Institutional Review Board approvals for research involving human subjects for all participating sites. Assess the public health impact of the research and assure translation of promising practices, programs, interventions, and other results from the research; and Make recommendations on requests for changes in scope, objectives, and/or budgets that deviate from the approved peer-reviewed application. Promote translation of promising practices, programs, interventions, and other results from the research. Promote translation of promising practices, programs, interventions, and other results from the research. Research Aims: list each research aim/project a) Research Aim/Project: purpose, status (met, ongoing, and unmet), challenges, successes, and lessons learned b) Leadership/Partnership: list project collaborations and describe the role of external partners. This section should be understandable to a variety of audiences, including policy makers, practitioners, public health programs, healthcare institutions, professional organizations, community groups, researchers, and other potential users. Or, if they cannot be applied yet, this section should address which research findings may be translated, how these findings can guide future research or related activities, and recommendations for translation. If relevant, describe how the results of this project could be generalized to populations and communities outside of the study. Questions to consider in preparing this section include: How will the scientific findings be translated into public health practice or inform public health policy? How will the project improve or effect the translation of research findings into public health practice or inform policy? How will the research findings help promote or accelerate the dissemination, implementation, or diffusion of improvements in public health programs or practices? How will the findings advance or guide future research efforts or related activities? This section should address improvements in public health as measured by documented or anticipated outcomes from the project. Questions to consider in preparing this section include: How will this project lead to improvements in public health? How will the findings, results, or recommendations been used to influence practices, procedures, methodologies, etc.? How will the findings, results, or recommendations contributed to documented or projected reductions in morbidity, mortality, injury, disability, or disease? New Budget Period Proposal: Detailed operational plan for continuing activities in the upcoming budget period, including updated 28 of 57 Detailed operational plan for continuing activities in the upcoming budget period, including updated Measures of Effectiveness for evaluating progress during the upcoming budget period. Project Timeline: Include planned milestones for the upcoming year (be specific and provide deadlines). New Budget Period Budget: Detailed line-item budget and budget justification for the new budget period. If no publication or presentations have been made at this stage in the project, simply indicate “Not applicable: No publications or presentations have been made. Investigators should include any updates to the project’s data collection such as changes to initial data collection plan, challenges with data collection, and recent data collected. Additional Reporting Requirements: Human Subjects Education Requirement: Provide certification, for any new key personnel or other significant contributors involved in the design or conduct of research involving human subjects, that they have completed an educational program in the protection of human subjects. Failure to submit the required information in a timely manner may adversely affect the future funding of this project. If the information cannot be provided by the due date, you are required to submit a letter explaining the reason and date by which the Grants Officer will receive the information. Organizations may verify their current registration status by running the “List of Commons Registered Organizations” query found at: https://era. This registration must be done by an organizational official or their delegate who is already registered in the Commons. This section should be understandable to a variety of audiences, including policy makers, practitioners, public health programs, healthcare institutions, professional organizations, community groups, researchers and other potential end users. If applicable, describe how the findings could be generalized and scaled to populations and communities outside of the funded project. Public Health Relevance and Impact: This section should address improvements in public health as measured by documented or anticipated outcomes from the project. Please include any additional dissemination efforts that did or will result from the project. Final Data Management Plan: Applicants must include an updated final Data Management Plan that describes the data collected, the location of where the data is stored (example: a repository), accessibility restrictions (if applicable), and the plans for long term preservation of the data. Agency Contacts 30 of 57 We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants. Eastern Time We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants. Authority and Regulations Awards are made under the authorization of Sections of the Public Health Service Act as amended and under the Code Federal Regulations.
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