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An intravenous cortcosteroid such as hydrocortsone has an onset of acton that is delayed by several hours but should be given to help prevent later deterioraton in severely afected patents buy clozapine 50mg on-line depression with anxiety. Furthertreatmentofanaphylaxismayincludeintravenousfuids clozapine 25 mg otc anxiety disorders in children, an intravenous vasopressor such as dopamine discount clozapine 50mg on line depressedtest.com review, intravenous aminophylline or injected or nebulized bronchodilator buy clozapine 50 mg cheap depression therapist, such as salbutamol. Vital Functons: Maintain an open airway; give oxygen by mask, restore blood pressure (lay patent fat, raise feet) 3. Dose Intramuscular injecton Anaphylaxis: preferable site is the midpoint in anterior thigh [1:1000 soluton]. Slow intravenous injecton When there is doubt regarding adequacy of circulaton and absorpton from the intramuscular site; slow intravenous injecton of 1:10000 (10 mg/ml) soluton be injected in severely ill patents only. Contraindicatons Narrow angle glaucoma, organic brain dam- age, cardiac dilaton, coronary insufciency. Precautons Hyperthyroidism, hypertension, diabetes mellitus, heart disease, arrhythmias, cerebrovascular disease; second stage of labour; elderly; interactons (Appendix 6c); pregnancy (Appendix 7c); lactaton (Appendix 7b). Adverse Efects “Epinephrine fastness”, tachycardia and arrhythmias, hypertension, tremor, anxiety, sweatng, nausea, vomitng, weakness, hyperglycaemia, dizziness, pulmonary oedema have all been reported; headache common. Chlorpheniramine* Pregnancy Category-C Schedule H,G Indicatons Symptomatc relief of allergy, allergic rhinits (hay fever); conjunctvits; urtcaria; insect stngs and pruritus of allergic origin; adjunct in the emergency treatment of anaphylactc shock and severe angioedema. Contraindicatons Prostatc enlargement, urinary retenton; ileus or pyloroduodenal obstructon; asthma; child under 1 year; hypersensitvity, narrow angle glaucoma, pregnancy (Appendix 7c), lactaton (Appendix 7b). Precautons Performing works requiring utmost alertness such as vehicle driving, operatng machines etc within 24 h of taking the drug should be avoided. Lactaton (Appendix 7b); renal and hepatc impairment (Appendix 7a); epilepsy; interactons (Appendix 6a); atropic gastrits, elderly. Adverse Efects Drowsiness (rarely, paradoxical stmulaton with high doses, or in children or elderly), hypotension, headache, palpitatons, psychomotor impairment, urinary retenton, dry mouth, blurred vision, gastrointestnal disturbances; liver dysfuncton; blood disorders; also rash and photosensitvity reactons, hypersensitvity reactons (including bronchospasm, angioedema, anaphylaxis); sweatng and tremor, injectons may be irritant; fatulence, diarrhoea. Cinnarizine Pregnancy Category-C Schedule H Indicatons Moton sickness, nausea, vomitng, vertgo and tnnitus associated with Meniere disease and other middle ear disorders, as a nootropic drug, adjunct therapy for symptoms of peripheral arterial disease. Dose Oral Moton sickness Adult: 30 mg 2 hr before travel and 15 mg every 8 hr during travel if needed. Precautons Hypotension, patents should not drive or operate machinery, pregnancy (Appendix 7c), lactaton, elderly, children and neonates, interactions (Appendix 6c). Precautons Increased susceptbility to and severity of infecton; actvaton or exacerbaton of tuberculosis, amoebiasis, strongyloidiasis;risk of severe chickenpox in non-immune patent (varicella-zoster immunoglobulin required if exposed to chickenpox); avoid exposure to measles (normal immunoglobulin possibly required if exposed); diabetes mellitus; peptc ulcer; hypertension; precautons relatng to long-term use of cortcosteroids; glaucoma, epilepsy; drug should not be abruptly withdrawn; interactons (Appendix 6c), lactaton (Appendix 7b). Adverse Efects Nausea, dyspepsia, malaise, hiccups; hypersensitvity reactons including anaphylaxis; perineal irritaton afer intravenous administraton; adverse efects associated with long-term cortcosteroid treatment; hyperglycaemia, abdominal distension, angioedema, bradycardia, acne, erythema, Cushing’s syndrome, oropharangeal candidiasis, hypothalamic pituitary adrenal axis suppression. Fexofenadine Pregnancy Category-C Schedule H Indicatons Allergic rhinits, urtcaria. Child- (6 month to 2 years): 15 mg twice daily, more than 2 years: 30 mg twice daily. Adverse Efects Dizziness, stomach discomfort, pain in extremity, back pain, vomitng, diarrhoea, upper respiratory tract infecton, headache, dysmenorrhoea. Dose Intramuscular injecton or slow intravenous injecton or intravenous infusion Adult-100 mg to 500 mg, 3 to 4 tmes in 24 h or as required. Contraindicatons Not relevant to emergency use but for contra-indicatons relatng to long-term use; ulcers. Precautons Not relevant to emergency use but for precautons relatng to long-term use, interactons (Appendix 6d), lactaton (Appendix 7b), pregnancy (Appendix 7c). Adverse Efects Adverse efects associated with long-term cortcosteroid treatment; opportunistc infectons. Levocetrizine Pregnancy Category-B Schedule H Indicatons Allergic rhinits, chronic urtcaria. Dose Oral Rhinits, chronic urtcaria: Adult & children (>12 years) - 5 mg once daily in the evening. Contraindicatons Hypersensitvity, end-stage renal disease with creatnine clearance < 10 ml/min. Adverse Efects Somnolence, fatgue, dry mouth, nasopharyngits have been reported in adults. Storage Store protected from heat, light and moisture at a temperature not exceeding 30⁰C. Noradrenaline Pregnancy Category-C Indicatons Acute hypotension, adjunct in cardiac arrest, upper gastrointestnal haemorrhage. Reconsttuton Dilute with 5% glucose injecton, with or without sodium chloride; diluton with sodium chloride injecton alone is not recommended. Contraindicatons Hypertension, pregnancy (Appendix 7c), patents with peripheral or mesenteric vascular thrombosis unless necessary as a life-saving procedure. Adverse Efects Elevaton of blood pressure, bradycardia, peripheral ischemia, arrhythmias, anxiety, transient headache, respiratory difculty, extravasaton necrosis at injecton site. Pheniramine* Pregnancy Category-C Schedule H Indicatons Symptomatc relief of allergy; allergic rhinits; urtcaria. Contraindicatons Epilepsy; pregnancy (Appendix 7c); acute asthma; acute porphyria; symptomatc prostatc hypertrophy; neonates and premature infants. Precautons Glaucoma; driving or operatng machinery; asthma or severe cardiovascular disease, pregnancy (Appendix 7c), lactaton. Dose Oral Adult and Child- Initally up to 10 to 20 mg daily in divided doses (severe diseases up to 60 mg), preferably afer breakfast. Contraindicatons Untreated systemic infecton; administraton of live virus vaccines; hypersensitvity. Adverse Efects Nausea, dyspepsia, malaise, hiccups; hyper- sensitvity reactons including anaphylaxis; supraclavicular lump, fragile skin. The disease mainly afects the older populaton and is the most common cause of dementa (early stage). As the disease advances behavioural changes such as confusion, irritability and aggression, mood swings, language break- down, long term loss of memory etc. The biochemical mechanisms involved in its pathogenesis are suggested to be the accumulaton of abnormally folded amyloid β and τ proteins in the brain, involvement of infammatory cytokines, alteraton in distributon of diferent neurotrophic factors and expression of their receptors etc. Alzheimer’s Associaton has pointed out 10 warning symp- toms for this disease which are as under: 1. Loss of initatve There is no cure for this disease, drug therapy is mainly symp- tomatc and palliatve in nature. Contraindicatons Hypersensitvity, severe hepatc and renal impairment, pregnancy (Appendix 7c), lactaton, not recommended for children. Adverse Efects Nausea, vomitng, diarrhoea, fatgue, insomnia, muscle cramps, bradycardia, convulsions, gastrointestnal, haemorrhage, hepatts, urinary incontnence, infuenza, pruritus, increased liver transaminases. Galantamine Pregnancy Category-B Schedule H Indicatons To treat the symptoms of mild to moderate Alzheimer’s disease, Dementa syndrome. Contraindicatons Hypersensitvity to galantamine, severe kidney and liver problems, pregnancy (Appendix 7c), lactatng mothers, children. Precautons Patents with asthma or lung disease, epilepsy, stomach ulcer, take plenty of fuids during treatment. Adverse Efects Diarrhoea, nausea, anorexia and weight loss, chest pain or shortness of breath. Memantne Pregnancy Category-B Indicatons Treatment of moderate to severe dementa of Alzheimer’s disease.
M anufacturing (Direct com pression) M ix all com ponents buy clozapine uk depression keeps coming back, pass through a sieve and press with very low com pression force order clozapine visa bipolar depression laziness. M anufacturing (Direct com pression) M ix all com ponents buy clozapine amex depression symptoms eating, pass through a sieve and press with low com pres- sion force best buy for clozapine depression gene test. Properties of the solution The obtained clear and som ewhat yellowish solution had got the pH value 5. Rem arks To prevent of discolouration of Kollidon in the solution during storage 0. Chem ical stability (20–25 °C, dark) 0 M onths 6 M onths 12 M onths Tretinoin content 100% 100% 96% There was no loss of alpha bisabolol during these 12 m onths. Rem ark It is im portant to protect this form ulation against light to avoid the isom erization and degradation of tretinoin. Rem ark It is im portant to protect the gel against light to avoid the isom erization and degradation of tretinoin. Chem ical stability (20–25 °C, dark) M onths Tretinoin content Loss of tretinoin 0 0. Rem ark It is im portant to protect the gel against light to avoid the isom erizatio- nand degradation of tretinoin. Chem ical stability (20–25 °C, dark) No loss of tretinoin was m easured after 1 year. Rem ark It is im portant to protect the gel against light to avoid the isom erization and degradation of tretinoin. Chem ical stability (20–25 °C, protected from light) M onths Tretinoin content 0 0. Rem ark It is very im portant to protect this form ulation from light to avoid the isom erization and degradation of tretinoin. M anufacturing (Direct com pression) M ix all com ponents, pass through a sieve and press with low com pres- sion force. Rem ark If the content uniform ity does not m eet the requirem ents it would be recom m ended to prepare a prem ix of the active ingredient with a sm all part of the Ludipress or with lactose m onohydrate before m ixing with the other com ponents of the form ulation. M anufacturing (Direct com pression) M ix all com ponents, pass through a sieve and press with very low com pression force. Rem ark If the content uniform ity does not m eet the requirem ents it would be recom m ended to prepare a prem ix of the active ingredient with a sm all part of the Ludipress or with lactose m onohydrate before m ixing with the other com ponents of the form ulation. Rem ark The addition of salts like sodium chloride would be possible but the consistency could be changed by such m odification. After the am poules have been heat-sterilized, they should be shaken for a short tim e, while they are still hot, to elim inate any separation of the phases that m ay have occurred. Physical stability (20–25 °C, protected from light) No change of the clarity after som e days. Rem ark Perhaps it would be recom m endable to use an other m agnesium salt instead of the sulfate to avoid any precipitation of calcium sulfate during storage. After the am poules have been heat-sterilized, they should be shaken for a short tim e, while they are still hot, to elim inate any separation of the phases that m ay have occurred. Physical stability (20–25 °C, protected from light) No change of the appearance during 2 years. Chem ical stability of vitam in A (2 years, protected from light) Room tem perature: 9% loss after 1 year, 16% loss after 2 years. After the am poules have been sterilized, they should be briefly shaken whilst they are still hot, to elim inate any separation of the phases. Properties of the em ulsion Pale yellow m ilky, stable em ulsion with a viscosity of less than 30 m Pa ·s. Chem ical stability of vitam in A (Stress test at 40°C) 1 M onth 2 M onths 3 M onths Vitam in A content 92% 86% 81% 5. If the obtained yellow solution is not com pletely clear heat for som e m inutes m ore at 65 °C. After the am poules have been heat-sterilized, they should be shaken for a short tim e, while they are still hot, to elim inate any separation of the phases that m ay have occurred. Add very slowly the solution of the preservative in water, also heated to 65°C, with vigorous stirring. Heat the solution of the preservative in water to the sam e tem perature and add it slowly to the well stirred vitam in m ixture. After the am poules have been heat-sterilized, they should be shaken for a short tim e, while they are still hot, to elim inate any separation of the phases that m ay have occured. Physical stability (20–25 °C, protected from light) No change was observed during 1 year. Rem arks It m ust be tested if the ethanol concentration has a sufficient preserva- tive efficiency. After the am poules have been heat-sterilized, they should be shaken for a short tim e, while they are still hot, to elim inate any separation of the phases that m ay have occured. M anufacturing Heat the m ixture I to about 65 °C, stir very well and add slowly the hot water (65 °C). Properties of the solutions Yellow clear or slightly opalescent solutions of low viscosity. Physical stability (20–25 °C, protected from light) No change of clarity and colour after 1 year. After the am poules have been heat-sterilized, they should be shaken for a short tim e, while they are still hot, to elim inate any separation of the phases that m ay have occurred. M anufacturing Dissolve butylhydroxytoluene in the warm vitam in A, add Crem ophor and m ix with the m olten Lutrol E grades. M anufacturing Granulate the dicalcium phosphate with Kollidon 30, dissolved in isopropanol or water and pass through a 0. M ix the obtained dried granules with the other com ponents, sieve and press with high com pression force using a vibrating hopper. Properties of the granules Colour: Yellow granules Flowability: Very good Dispersibility: 2. Rem ark 5 m l of Evening Prim rose oil (Epopure‚, Prim a Rosa, South Africa) contain 3. Properties of the granules Yellow hom ogeneous granules dispersible in cold water. Adm inistration About 1 g of the granules (= 1 sachet) correspond to two daily vitam in B and vitam in C requirem ents of adults. Chem ical stability of the granules (20–25 °C) Vitam in After production 4 M onths 6 M onths B1 100 % 100 % 93 % B2 100% 93% 80% B3 100 % 100 % 98 % B6 100 % 100 % 97 % B12 100 % 100 % 100 % C 100% 100% 97% 6. Rem ark Due to the high loss of riboflavin phosphate sodium it should be substi- tuted by riboflavin. Properties of the solution Yellow clear taste full solution having a density of 1. Rem ark For stability reasons it would be better to substitute thiam ine hydro- chloride by thiam ine m ononitrate in form ulation No. M anufacturing Dissolve the sucrose in the heat m ixture of glycerol, propylene glycol and water, cool to room tem perature and dissolve the other com ponents to obtain a clear solution. Chem ical stability of vitam in B1 (40°C, closed) 0 M onth 6 M onths 12 M onths Form ulation No.
Clinically important drug interactions: Drugs that increase effects/toxicity of valacyclovir: probenecid buy clozapine once a day depression test bc, cimetidine best clozapine 100 mg anxiety quiz online. Editorial comments • It is most important to institute valacyclovir therapy as soon as possible following signs or symptoms of herpes zoster infec- tion generic 100mg clozapine otc mood disorder research. It is unknown how effective treatment would be more than 72 hours after onset of rash generic 50 mg clozapine amex anxiety bible verses. Such recurrences are rare and may indicate an underlying malignancy or dysfunction of the immune system. Valproic Acid Brand names: Depacon (valproate sodium injection), Depakote (tablets), Depakene (capsules, syrup). Not recommended for treatment of mania in children <18 years or of migraine in children <16 years. Food: Capsules or tablets should be swallowed whole to avoid irritation of oral mucosa. Contraindications: Liver disease or hepatic dysfunction, hyper- sensitivity to valproic acid. Warnings/precautions • Use with caution in patients with previous history of liver dis- ease, patients on multiple anticonvulsants (see drug interactions below), congenital metabolic disorders, organic brain disease, severe seizures accompanied by mental retardation. Advice to patient • Do not drive or perform other activities requiring alertness until effects of the drug are known. Adverse reactions • Common: Nausea, vomiting, abdominal cramping, dyspepsia, diarrhea, anorexia. Clinically important drug interactions • Drugs that increase effects/toxicity of valproic acid: aspirin, alcohol, felbamate, rifampin, diazepam. Perform platelet counts and coagulation tests before initiating therapy and periodically thereafter. Food: Advise patients to limit foods containing potassium: salt substitutes, orange juice, bananas. Contraindications: Hypersensitivity to valsartan, anuria, hyper- sensitivity to sulfonamides (thiazide diuretics, oral hypo- glycemic drugs). Adjustment of dosage • Kidney disease: Creatinine clearance 40–90 mL/min: admin- ister q24h; creatinine clearance 10–20 mL/min: administer q96h; creatinine clearance <10 mL/min: administer 5–7 days. Warnings/precautions • Use with caution in patients with: hearing impairment, intes- tinal obstruction, and in patients receiving other potentially nephrotoxic or ototoxic drugs, kidney disease, elderly. Adverse reactions • Common: nausea, vomiting, taste disturbances, rash on face and upper body (parenteral administration). Clinically important drug interactions: Vancomycin increases effects/toxicity of aspirin, aminoglycosides, cyclosporine, loop diuretics, nondepolarizing neuromuscular blockers, general anesthetics. If extrava- sation is suspected, remove catheter and discontinue adminis- tration. It is used to treat entero- coccal infections resistant to ampicillin, preferable in combination with an aminoglycoside. Contraindications: Chronic nephritis (until controlled), hyper- sensitivity to beef/pork proteins, hypersensitivity to vasopressin, coronary artery disease, angina pectoris. Warnings/precautions • Use with caution in patients with seizures, asthma, migraine, heart failure, goiter, atherosclerosis. Adverse reactions • Common: hypertension, headache, fever, skin pallor, tremor, abdominal cramps, nausea, diaphoresis. Clinically important drug interactions • Drugs that increase effects/toxicity of vasopressin: carbamaze- pine, clofibrate, chloropropamide, ganglionic blockers, fludro- cortisone, phenformin, urea. Parameters to monitor • Intake of fluids and urinary and other fluid output to minimize renal toxicity. Editorial comments • Physician should be advised that dosage for treating diabetes insipidus is highly variable. Adjustment of dosage • Kidney disease: Mild to moderate: reduce dose by 25%; severe: reduce dose by 50%. Increase to 240 mg in morning and 120 mg in evening and then 240 mg q12h if needed. Sit at the edge of the bed for several minutes before standing, and lie down if feeling faint or dizzy. Clinically important drug interactions • Drugs that increase effects/toxicity of calcium blockers: cimet- idine, β blockers, cyclosporine. Impaired renal function prolongs duration of action and increases tendency for toxicity. If anginal pain is not reduced at rest or during effort, reassess patient as to medication. If reepithelialization has not occurred in 21 days, other therapy should be considered. Adverse reactions • Common: lacrimation, irritation, infection of the conjunctiva. Editorial comments • May be administered together with topical gentamicin, eryth- romycin, and chloramphenicol. Mechanism of action: Disrupts cell division in metaphase by inhibition of microtubule formation. Warnings/precautions • Use with caution in patients with decreased bone marrow reserve, liver disease. Decrease doses in patients receiving other chemotherapy or with recent radiation therapy. Advice to patient • Use two forms of birth control including hormonal and barrier methods. Clinically important drug interaction • Drugs that increase effects/toxicity of vinblastine: antineo- plastic agents (cause bone marrow suppression), mitomycin (bronchospasm), erythromycin, ritonavir. If a medication-induced neuropathy is suspected, discontinue treatment immediately. Treat with peroxide, tea, topical anesthetics such as benzocaine or lidocaine, or antifungal drug. This toxic effect may occur within a few minutes of mitomycin C administration or may occur up to 2 weeks following administration of a single dose of mitomycin. Signs and symptoms include peripheral neuropathy, headache, confusion, urinary retention, and seizures. Mechanism of action: Inhibits synthesis of hepatic vitamin K-dependent clotting factors. Contraindications: Pregnancy, hemorrhagic disorders, hemo- philia, blood dyscrasias, thrombocytopenia purpura, malignant hypertension, recent surgery (eg, brain, eye), head injury, threatened abortion, spinal puncture, hypersensitivity to war- farin. Advice to patient • Carry identification card at all times describing disease, treatment regimen, name, address, and telephone number of treating physician.
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors clozapine 100 mg cheap mood disorder with depressive features. Mannose-coated liposomal hamycin in the treatment of experimental leishmaniasis in hamsters purchase clozapine 100 mg visa anxiety disorder in children. Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes clozapine 100 mg low price anxiety meds. Leishmaniasis in Bahia clozapine 100mg generic mood disorder bipolar 1, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Molecular and cellular effects of hexadecylphosphocholine (Miltefosine) in human myeloid leukaemic cell lines. Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation. Silent infection of bone marrow-derived dendritic cells by Leishmania mexicana amastigotes. Selective impairment of protein kinase C isotypes in murine macrophage by Leishmania donovani. Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India. Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum. Epidemiological surveys confirm an increasing burden of cutaneous leishmaniasis in north-east Brazil. Transcriptional silencing in yeast isassociated with reduced nucleosome acetylation. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis. Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes. A policy for leishmaniasis with respect to the prevention and control of drug resistance. Correlation between enhanced oxidative metabolism and leishmanicidal activity in activated macrophages from healer and nonhealer mouse strains. Molecular characterization of a kinesin- related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. Leishmania infantum: stage-specific activity of pentavalent antimony related with the assay conditions. Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro. Antileishmanial activity of selected compounds in dogs experimentally infected with Leishmania donovani. A meta-analysis of the diagnostic performance of the direct agglutination test and rK39 dipstick for visceral leishmaniasis. Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion. Regulation of vsg expression site transcription and switching in Trypanosoma brucei. C-reactive protein binds to a novel ligand on Leishmania donovani and increases uptake into human macrophages. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals. Locus specificity determinants in the multifunctional yeast silencing protein Sir2. Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation. Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes. Ligation of Fc receptor of macrophages stimulates protein kinase C and anti-leishmanial activity. Spraying houses in the Peruvian Andes with lambda-cyhalothrin protects residents against cutaneous leishmaniasis. Microbial compounds selectively induce Th1 cell- promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. Visceral leishmaniasis in eastern Sudan: parasite identification in humans and dogs; host-parasite relationships. Leishmania donovani lipophosphoglycan disrupts phagosome microdomains in J774 macrophages. Trypanothione- dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate. Improvement of a direct agglutination test for field studies of visceral leishmaniasis. Stage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes. American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. In vitro antileishmanial activity of amphotericin B loaded in poly(epsilon-caprolactone) nanospheres. Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation. Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism. Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Anticancer compounds as leishmanicidal drugs: challenges in chemotherapy and future perspectives. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Ultrastructural changes in parasites induced by nanoparticle-bound pentamidine in a Leishmania major/mouse model.